
Dushyant Patel Introduction
S.K.P.C.P.E.R., Kherva 6 M .Pharm. Thesis
1.2.4 RECOMMENDED DOSAGE:
¾ People over the age of 12 should be started on 300 mg GBP taken three times a day. The
dose can be increased up to a total of 1,800 mg per day. In some instances, doses of up to
3,600 mg per day have been tolerated.
¾ Children should receive a dosage of 10–15 mg per kg of body weight per day, divided
into three equal doses.
¾ Chronic pain may be treated with 300–3,600 mg per day, divided into three equal doses.
¾ When GBP is used for bipolar disorder, the starting dose is usually 300 mg taken at
bedtime. Depending on the patient's response, the dose can be increased every four to
seven days. Many people receive maximum therapeutic benefit at 600 mg per day,
although some people have required up to 4,800 mg per day.
1.2.5 SIDE EFFECTS:
¾ Patients who experience the following side effects of GBP should check with their doctor
immediately. These include more common side effects, such as unsteadiness, clumsiness,
and uncontrollable back-and-forth eye movements or eye rolling. Less common side
effects include depression, irritability, other mood changes or changes in thinking, and
decreased memory. Rare side effects include pain in the lower back or side, difficulty
urinating, fever and/or chills, cough, or hoarseness.
¾ Children under age 12 who have the following more common side effects should also
check with their doctor immediately: aggressive behavior, irritability, anxiety, difficulty
concentrating and paying attention, crying, depression, mood swings, increased
emotionality, hyperactivity, suspiciousness or distrust.
¾ Multiple side effects often occur when a patient starts taking GBP. While these side
effects usually go away on their own, if they last or are particularly troublesome, the
patient should consult a doctor. More common side effects that occur when first starting
to take GBP include blurred or double vision, muscle weakness or pain, swollen hand,
feet, or legs, trembling or shaking, and increased fatigue or weakness. Less common side
effects that occur when initiating GBP treatment include back pain, constipation,
decreased sexual drive, diarrhea, dry mouth and eyes, frequent urination, headache,
indigestion, low blood pressure, nausea, ringing in the ears, runny nose, slurred speech,
difficulty thinking and sleeping, weight gain, twitching, nausea and/or vomiting,
weakness.
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